We develop a vertex model to describe the morphologies of cell packings and cell shapes in growing epithelia. The ground state packing of identical cells is in many cases a perfect hexaginal lattice. Cell division generates disorder which results in irregular cell packings. Biophyscal properties of cells determine the geometry and topology of the network of cell junctions. We compare our simulations to experimental data of cell packings in the developing fly wing. We quantify two biophysical parameters describing cell mechanical properties.
Kinetics of Morphogen Gradient Formation
A. Kicheva, P. Pantazis, B. Bollenbach, Y. Kalaidzidis, T. Bittig, F. Jülicher and M. González-Gaitán
Science 315, 521 (2007)
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