group leader

Group leader

Michael Hiller

Research Group Leader

Scientific Career

  • since 2018 Senior Research Group Leader, jointly at the Max Planck Institute for the Physics of Complex Systems, Dresden and the Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
  • 2011-2017 Research Group Leader, jointly at the Max Planck Institute for the Physics of Complex Systems, Dresden and the Max Planck Institute of Molecular Cell Biology and Genetics, Dresden
  • 2008-2011 Postdoctoral work at Stanford University, Department of Developmental Biology, USA
  • 2007-2008 Postdoctoral work at University of Freiburg, Bioinformatics Group, Germany
  • 2002-2007 PhD in Bioinformatics, University of Jena and University of Freiburg, Germany

Awards

  • German Life Science Award (2013)
  • Long-term Postdoc Fellowship from the Human Frontier Science Program (HFSP, 2009-2011)
  • Postdoc fellowship from the German Research Foundation (2008-2009)

Selected publications

Lee JH, Lewis KM, Moural TW, Kirilenko B, Bogdanova B, Prange G, Koessl M, Huggenberger S, Kang C, and Hiller M #. Molecular parallelism in fast-twitch muscle proteins in echolocating mammals. Science Adv, 4(9), eaat9660, 2018

Sharma V, Lehmann T, Stuckas H, Funke L, and Hiller M #. Loss of INSL3 and RXFP2 genes in afrotheria shows that testicular descent is the ancestral condition in placental mammals. PLoS Biology 16(6), e2005293, 2018, some Press: New York Times, Smithsonian Magazine, Inside Science, Scienmag

Florio M, Heide M, Pinson A, Brandl H, Albert M, Winkler S, Wimberger P, Huttner WB #, Hiller M #. Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex. Elife, 7, 2018, F1000

Sharma V, Hecker N, Roscito JG, Foerster L, Langer BE, and Hiller M #. A genomics approach reveals insights into the importance of gene losses for mammalian adaptations. Nature Communications, 9(1), 1215, 2018

Nowoshilow S, Schloissnig S #, Fei JF, Dahl A, Pang AWC, Pippel M, Winkler S, Hastie AR, Young G, Roscito JG, Falcon F, Knapp D, Powell S, Cruz A, Cao H, Habermann B, Hiller M #, Tanaka EM #, Myers E. (2018) The axolotl genome and the evolution of key tissue formation regulators. Nature, 554(7690), 50-55.

Sharma V, Hiller M # (2017) Increased alignment sensitivity improves the usage of genome alignments for comparative gene annotation. Nucleic Acids Res, 45(14) 8369-8377.

Prudent X, Parra G, Schwede P, Roscito JG, Hiller M # (2016). Controlling for phylogenetic relatedness and evolutionary rates improves the discovery of associations between species’ phenotypic and genomic differences. Mol Biol Evol, 33(8), 2135-5.
See also MBE News.

Hiller M #, Schaar BT, Indjeian VB, Kingsley DM, Hagey LR, and Bejerano G. (2012): A “forward genomics” approach links genotype to phenotype using independent phenotypic losses among related species. Cell Reports, 2(4), 817-823.
Read more on F1000 and HFSP

Hiller M #, Findeiss S, Lein S, Marz M, Nickel C, Rose D, Schulz C, Backofen R, Prohaska SJ, Reuter G and Stadler PF. (2009):  Conserved Introns Reveal Novel Transcripts in Drosophila melanogaster. Genome Res. 19(7), 1289-1300

Hiller M*, Huse K*, Szafranski K, Jahn N, Hampe J, Schreiber S, Backofen R, and Platzer M. (2004): Widespread occurrence of alternative splicing at NAGNAG acceptors contributes to proteome plasticity. Nature Genet. 36(12), 1255-7

Popular Science

Funding

In addition to generous funding from the Max Planck Society, our research is supported by