# Highlights

Publication Highlights

### Phase separation provides a mechanism to reduce noise in cells

Expression of proteins inside cells is noisy, causing variability in protein concentration among identical cells. A central problem in cellular control is how cells cope with this inherent noise. Compartmentalization of proteins through phase separation has been suggested as a potential mechanism to reduce noise, but systematic studies to support this idea have been missing. In this study, we used a physical model that links noise in protein concentration to theory of phase separation to show that liquid droplets can effectively reduce noise. We provide experimental support for noise reduction by phase separation using engineered proteins that form liquid-like compartments in mammalian cells. Thus, phase separation can play an important role in biological signal processing and control.

Klosin et al., Science 366, 464 (2020)
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Publication Highlights

### Active Forces Shape the Metaphase Spindle through a Mechanical Instability

The metaphase spindle is a dynamic structure orchestrating chromosome segregation during cell division. Recently, soft matter approaches have shown that the spindle behaves as an active liquid crystal. Still, it remains unclear how active force generation contributes to its characteristic spindle-like shape. Here we combine theory and experiments to show that molecular motor-driven forces shape the structure through a barreling-type instability. We test our physical model by titrating dynein activity in Xenopusegg extract spindles and quantifying the shape and microtubule orientation. We conclude that spindles are shaped by the interplay between surface tension, nematic elasticity, and motor-driven active forces. Our study reveals how motor proteins can mold liquid crystalline droplets and has implications for the design of active soft materials.

Oriola et al., PNAS (2020)
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Publication Highlights

### Nonlinear Hall Acceleration and the Quantum Rectification Sum Rule

Electrons moving in a Bloch band are known to acquire an anomalous Hall velocity proportional to the Berry curvature of the band which is responsible for the intrinsic linear Hall effect in materials with broken time-reversal symmetry. Here, we demonstrate that there is also an anomalous correction to the electron acceleration which is proportional to the Berry curvature dipole and is responsible for the nonlinear Hall effect recently discovered in materials with broken inversion symmetry. This allows us to uncover a deeper meaning of the Berry curvature dipole as a nonlinear version of the Drude weight that serves as a measurable order parameter for broken inversion symmetry in metals. We also derive a quantum rectification sum rule in time reversal invariant materials by showing that the integral over frequency of the rectification conductivity depends solely on the Berry connection and not on the band energies. The intraband spectral weight of this sum rule is exhausted by the Berry curvature dipole Drude-like peak, and the interband weight is also entirely controlled by the Berry connection. This sum rule opens a door to search for alternative photovoltaic technologies based on the Berry geometry of bands. We also describe the rectification properties of Weyl semimetals which are a promising platform to investigate these effects.

O. Matsyshyn and I. Sodemann, Phys. Rev. Lett 123, 246602 (2019)
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Publication Highlights

### h/e oscillations in interlayer transport of delafossites

Microstructures can be carefully designed to reveal the quantum phase of the wave-like nature of electrons in a metal. Here, we report phase-coherent oscillations of out-of-plane magnetoresistance in the layered delafossites PdCoO2 and PtCoO2. The oscillation period is equivalent to that determined by the magnetic flux quantum, h/e, threading an area defined by the atomic interlayer separation and the sample width, where h is Planck’s constant and e is the charge of an electron. The phase of the electron wave function appears robust over length scales exceeding 10 micrometers and persisting up to temperatures of T > 50 kelvin. We show that the experimental signal stems from a periodic field modulation of the out-of-plane hopping. These results demonstrate extraordinary single-particle quantum coherence lengths in delafossites.

C. Putzke et al., Science 368, 1234 (2020)
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Publication Highlights

### Prethermalization without Temperature

While a clean, driven system generically absorbs energy until it reaches “infinite temperature,” it may do so very slowly exhibiting what is known as a prethermal regime. Here, we show that the emergence of an additional approximately conserved quantity in a periodically driven (Floquet) system can give rise to an analogous long-lived regime. This can allow for nontrivial dynamics, even from initial states that are at a high or infinite temperature with respect to an effective Hamiltonian governing the prethermal dynamics. We present concrete settings with such a prethermal regime, one with a period-doubled (time-crystalline) response. We also present a direct diagnostic to distinguish this prethermal phenomenon from its infinitely long-lived many-body localized cousin. We apply these insights to a model of the recent NMR experiments which, intriguingly, detected signatures of a Floquet time crystal in a clean three-dimensional material. We show that a mild but subtle variation of their driving protocol can increase the lifetime of the time-crystalline signal by orders of magnitude.

D. J. Luitz et al., Phys. Rev. X 10, 021046 (2020)
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Publication Highlights

### Extended Coherently Delocalized States in a Frozen Rydberg Gas

The long-range dipole-dipole interaction can create delocalized states due to the exchange of excitation between Rydberg atoms. We show that even in a random gas many of the single-exciton eigenstates are surprisingly delocalized, composed of roughly one quarter of the participating atoms. We identify two different types of eigenstates: one which stems from strongly-interacting clusters, resulting in localized states, and one which extends over large delocalized networks of atoms. These two types of states can be excited and distinguished by appropriately tuned microwave pulses, and their relative contributions can be modified by the Rydberg blockade and the choice of microwave parameters.

Abumwis et al., Phys. Rev. Lett. 124, 193401 (2020)
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Publication Highlights

### Hierarchy of Relaxation Timescales in Local Random Liouvillians

To characterize the generic behavior of open quantum systems, we consider random, purely dissipative Liouvillians with a notion of locality. We find that the positivity of the map implies a sharp separation of the relaxation timescales according to the locality of observables. Specifically, we analyze a spin-1/2 system of size $\ell$ with up to $n$-body Lindblad operators, which are $n$ local in the complexity-theory sense. Without locality ($n=\ell$), the complex Liouvillian spectrum densely covers a “lemon”-shaped support. However, for local Liouvillians ($n<\ell$), we find that the spectrum is composed of several dense clusters with random matrix spacing statistics, each featuring a lemon-shaped support wherein all eigenvectors correspond to $n$-body decay modes. This implies a hierarchy of relaxation timescales of n-body observables, which we verify to be robust in the thermodynamic limit. Our findings for n locality generalize immediately to the case of spatial locality, introducing further splitting of timescales due to the additional structure.

Wang et al., Phys. Rev. Lett. 124, 100604 (2020)
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Publication Highlights

### "Census" in the zebrafish's brain

Dresden scientists explore newborn, regenerated neurons The zebrafish is a master of regeneration: If brain cells are lost due to injury or disease, it can simply reproduce them - contrary to humans where this only happens in the fetal stage. However, the zebrafish is evolutionarily related to humans and, thus, possesses the same brain cell types as humans. Can a hidden regeneration potential also be activated in humans? Are therapies for stroke, craniocerebral trauma and presently incurable diseases such as Alzheimer's and Parkinson's possible?
Dresden scientists have now succeeded in determining the number and type of newly formed neurons in zebrafish; practically conducting a “census” in their brains. Following an injury, zebrafish form new neurons in high numbers and integrate them into the nervous system, which is the reason for their amazing brain regeneration ability. The study is a true collaboration project “made in Dresden”: Scientists from the Center for Regenerative Therapies TU Dresden (CRTD) combined their expertise in stem cell biology with complex bio-informatic analyses from the Max Planck Institute for the Physics of Complex Systems (MPI-PKS) and the Center for Systems Biology Dresden (CSBD) and with the latest sequencing methods from the DRESDEN-concept Genome Center.
For their study now published in Development, the team led by Christian Lange and Michael Brand from the CRTD used adult transgenic zebrafish in whose forebrain they were able to identify the newborn neurons. The forebrain of the zebrafish is the equivalent to the human cerebral cortex, the largest and functionally most important part of the brain. Together with the Steffen Rulands group at the MPI-PKS and the CSBD, the interdisciplinary research team investigated the newborn and mature neurons as well as brain stem cells using single cell sequencing. Thus, they discovered specific markers for newborn neurons and were able to comprehensively analyze which types of neurons are newly formed in the adult brain of the zebrafish. Together, researchers also investigated the data obtained from brain cells of mice and found that zebrafish and mice have the same cell types. This also makes these results highly relevant for humans.
"On the basis of this study, we will further investigate the regeneration processes that take place in zebrafish. In particular, we will study the formation of new neurons after traumatic brain damage and their integration," explains Michael Brand, CRTD Director and senior author of the study. "We hope to gain insights that are relevant for possible therapies helping people after injuries and strokes or suffering from neurodegenerative diseases. We already know that a certain regenerative ability is also present in humans and we are working on awakening this potential. The results of our study are also important for understanding the conditions under which transplanted neurons can network with the existing ones and thus could let humans re-gain their former mental performance.”
Original Publication: Christian Lange, Fabian Rost, Anja Machate, Susanne Reinhardt, Matthias Lesche, Anke Weber, Veronika Kuscha, Andreas Dahl, Steffen Rulands and Michael Brand: „Single cell sequencing of radial glia progeny reveals diversity of newborn neurons in the adult zebrafish brain”
Development 20 147, published 9 January 2020, doi: 10.1242/dev.185595
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Publication Highlights

### Phasonic Spectroscopy of a Quantum Gas in a Quasicrystalline Lattice

Phasonic degrees of freedom are unique to quasiperiodic structures and play a central role in poorly understood properties of quasicrystals from excitation spectra to wave function statistics to electronic transport. However, phasons are challenging to access dynamically in the solid state due to their complex long-range character and the effects of disorder and strain. We report phasonic spectroscopy of a quantum gas in a one-dimensional quasicrystalline optical lattice. We observe that strong phasonic driving produces a nonperturbative high-harmonic plateau strikingly different from the effects of standard dipolar driving. Tuning the potential from crystalline to quasicrystalline, we identify spectroscopic signatures of quasiperiodicity and interactions and map the emergence of a multifractal energy spectrum, opening a path to direct imaging of the Hofstadter butterfly.

S.V. Rajagopal et al., Phys. Rev. Lett. 123, 223201 (2019)
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Publication Highlights

### Emergent Quasicrystalline Symmetry in Light-Induced Quantum Phase Transitions

The discovery of quasicrystals with crystallographically forbidden rotational symmetries has changed the notion of the ordering in materials, yet little is known about the dynamical emergence of such exotic forms of order. Here we theoretically study a nonequilibrium cavity-QED setup realizing a zero-temperature quantum phase transition from a homogeneous Bose-Einstein condensate to a quasicrystalline phase via collective superradiant light scattering. Across the superradiant phase transition, collective light scattering creates a dynamical, quasicrystalline optical potential for the atoms. Remarkably, the quasicrystalline potential is “emergent” as its eightfold rotational symmetry is not present in the Hamiltonian of the system, rather appears solely in the low-energy states. For sufficiently strong two-body contact interactions between atoms, a quasicrystalline order is stabilized in the system, while for weakly interacting atoms the condensate is localized in one or few of the deepest minima of the quasicrystalline potential.

F. Mivehvar et al., Phys. Rev. Lett. 123, 210604 (2019)
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