|Tel. +49 351 871-1202
Fax. +49 351 871-1299
|List of Publications|
Theory of Biological Systems and Processes
The main focus of our research are theoretical approaches to understand dynamic processes in cells and tissues. Work on active cellular processes includes the study of cellular oscillations, cellular signaling and the cytoskeletal dynamics during cell division and cell motility. We furthermore study the biophysical basis of hearing. Finally, we investigate the biophysical properties and dynamics of tissues and epithelia. Based on the properties of individual cells and of cellular signaling systems, we are interested in the dynamics of developmental processes, for example wing development in the fruit fly.
|Research topics include:
Active cellular processes
Physics of the cytoskeleton and of motor proteins
Physics of Cell Division
Biophysics of hearing
|Discontinuous switching of position of two coexisting phases
We investigate how the positions of a condensed phase can be controlled by using concentration gradients of a regulator that influences phase separation. We find a novel first order phase transition at which the position of the condensed phase switches in a discontinuous manner. This mechanism could have implications for the spatial organisation of biological cells and provides a control mechanism for droplets in microfluidic systems.
|S. Krüger, C. A. Weber, J.-U. Sommer, F. Jülicher
New J. Phys. 20, 075009 (2018)
[PDF (1,2 MB)]
|Critical Point in Self-Organized Tissue Growth|
We present a theory of growth control inspired by biological tissues during development. We identify a critical point of the feedback dynamics where a graded profile of a secreted molecule regulates growth. At this critical point, growth is spatially homogeneous and concentration profiles exhibit exact scaling with size. We propose that the observed approximate growth homogeneity and scaling in the fly wing imaginal disk are signatures of this critical point.
|D. Aguilar-Hidalgo, S. Werner, O. Wartlick, M. Gonzalez-Gaitan, B. M. Friedrich
and F. Jülicher
Phys. Rev. Lett. 120, 198102 (2018)
[PDF (2,9 MB)]
|Chemical event chain model of coupled genetic oscillators|
We introduce a stochastic model of coupled genetic oscillators in which chains of chemical events involved in gene regulation and expression are represented as sequences of Poisson processes. We study the quality of noisy oscilations in different parameter regimes. we show that key features of the stochastic oscillations can be captured by an effective model for phase oscillators that are coupled by signals with distributed delays.
|D. J. Jörg, L. G. Morelli and F. Jülicher
Phys. Rev. E. 97, 032409 (2018)
[PDF (1,2 MB)]
|Last updated: September 21, 2018|