Publications

Research articles

  1. M. K. Sznurkowska, E. Hannezo, R. Azzarelli, S. Rulands, S. Nestorowa, C. J. Hindley, J. Nichols, B. Göttgens, M. Huch, A. Philpott, B. D. Simons,
    Defining lineage potential and fate behavior of precursors during pancreas development,
    Dev. Cell, in press (2018)
  2. S. Rulands*, H. J. Lee*, S. J. Clark, C. Angermueller, S. A. Smallwood, F. Krueger, H. Mohammed, W. Dean, J. Nichols, P. Rugg-Gunn, G. Kelsey, O. Stegle, B. D. Simons, W. Reik,
    Genome-scale oscillations in DNA methylation during exit from pluripotency,
    Cell Systems, advanced online publication (2018)
    Preprint on biorxiv: doi: https://doi.org/10.1101/338822
    Press release: Even stem cells have their ups and downs
  3. A. M. Lilja*, V. Rodilla*, M/ Huyghe, E. Hannezo, C. Landragin, O. Renaud, O. Leroy, S. Rulands, B. D. Simons, and S. Fre,
    Clonal analysis of Notch1 cells reveals the existence of unipotent stem cells that retain long-term plasticity in the embryonic mammary gland,
    Nature Cell Biology, available online (2018)
    Commentary: Mammary lineage restriction in development
  4. S. Rulands, F. Lescroart, S. Chabab, C. J. Hindley, N. Prior, M. K. Sznurkowska, M. Huch, A. Philpott, C. Blanpain, B. D. Simons,
    Universality of clone dynamics during tissue development,
    Nature Physics 14, 469-474 (2018)
    Cover Image
    Gurdon Institute news item
    Center for Systems Biology news item
    Max Planck Institute for the Physics of Complex Systems news item
    Commentary: Sensing and making sense of clonal fragmentation in developing tissues
  5. M. T. Tierney, M. J. Stec, S. Rulands, B.D. Simons, A. Sacco,
    Distinct coordination of muscle stem cell dynamics in response to homeostatic aging and tissue repair,
    Cell Stem Cell 22(1), p109-127.e3 (2018)
    Press release
  6. S. Rulands and B. D. Simons,
    Emergence and Universality in the regulation of cell fate,
    Current Opinion in Systems Biology 5, 57-62 (2017) 
  7. R. Azzarelli, C. Hurley, M. K. Sznurkowska, S. Rulands, L. Hardwick, I. Gamper, F. Ali, L. McCracken, C. Hindley, F. McDuff, S. Nestorowa, R. Kemp, K. Jones, B. Göttgens, M. Huch, G. Evan, B. D. Simons, D. Winton, A. Philpott, 
    Multi-site Neurogenin3 phosphorylation controls pancreatic endocrine differentiation,
    Developmental Cell 41(3), 274-286.e5 (2017)
  8. M. Aragona*, S. Dekoninck*, S. Rulands, S. Lenglez, G. Mascré, B. D. Simons, C. Blanpain, 
    Uncoupling stem cell proliferation, differentiation and migration during wound healing,
    Nature Communications, 14684 (2017) 
    Press release: Wound healing: the stem cell dynamics
  9. S. Rulands, B. D. Simons,
    Tracing cellular dynamics in tissue development, maintenance and disease,
    Current Opinion in Cell Biology 43, 38–45 (2016)
  10. A. Wuidart*, M. Ousset*, S. Rulands, B. D. Simons, A. Van Keymeulen, C. Blanpain,
    Quantitative lineage tracing strategies to resolve multipotency in tissue specific stem cells,
    Genes and Development 30, 1261-1277 (2016)
  11. Y. Wan, A. D. Almeida, S. Rulands, N. Chalour, L. Muresan, Y. Wu, B. D. Simons, J. He, W. A. Harris,
    The ciliary marginal zone of the zebrafish retina: clonal and time-lapse analysis of a continuously growing tissue,
    Development, 0950-1991 (2016)
  12. S. Chabab*, F. Lescroart*, S. Rulands*, N. Mathiah, B. D. Simons, C. Blanpain
    Uncovering the number and clonal dynamics of Mesp1 progenitors during heart morphogenesis,
    Cell Reports 14(1), 1-10 (2016) 
    Cover
  13. H. Boije, S. Rulands, S. Dudczig, B. D. Simons, W. A. Harris
    The independent probabilistic firing of transcription factors: A paradigm for clonal variability in the zebrafish retina,
    Developmental Cell, 34(5), 532–543 (2015)
  14. J. K. Watson, S. Rulands, A. C. Wilkinson, A. Wuidart, M. Ousset, A. Van Keymeulen, B. Göttgens, C. Blanpain, B. D. Simons, E. L. Rawlins
    Clonal dynamics reveal two distinct populations of basal cells in slow turnover airway epithelium,
    Cell Reports, 12(1), 90-101 (2015).
    Gurdon Institute news item
  15. F. Lescroart, S. Chabab, X. Lin, S. Rulands, C. Paulissen, A. Rodolosse, H. Auer, Y. Achouri, C. Dubois, A. Bondue, B. D. Simons, C. Blanpain,
    Early lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart development,
    Nature Cell Biology 16, 829-840 (2014).
  16. S. Rulands, D. Jahn, E. Frey,
    Specialization and bet hedging in heterogeneous populations,
    Physical Review Letters 113, 108102 (2014). [arxiv:1408.4912]
  17. M. Reiter*, S. Rulands*, E. Frey,
    Range expansion of heterogeneous populations,
    Physical Review Letters 112, 148103 (2014). [arxiv:1403.6333]
    LMU press release (German), NIM press release
  18. S. Rulands, A. Zielinski, E. Frey,
    Global attractors and extinction dynamics of cyclically competing species,
    Physical Review E 87, 052710 (2013). [arxiv:1305.0119]
  19. S. Rulands, B. Klünder, E. Frey,
    Stability of localized wave fronts in bistable systems,
    Physical Review Letters 110, 038102 (2013). [arxiv:1212.1036]
    LMU press release
  20. S. Rulands, T. Reichenbach, Erwin Frey,
    Three-fold way to extinction in populations of cyclically competing species,
    Journal of Statistical Mechanics L01003 (2011). [arXiv:1005.5704]

* denotes equal contributions.
† denotes joint corresponding authors.

Theses

  • S. Rulands
    Heterogeneity and spatial correlations in stochastic many-particle systems.
    From embryogenesis to evolution.
    PhD Thesis, Ludwig-Maximilians-University Munich (2013)
    Advisor: Prof. Erwin Frey
  • S. Rulands
    Statistics of rare events in reaction-diffusion systems
    Diploma Thesis, Ludwig-Maximilians-University Munich (2009)
    Advisor: Prof. Erwin Frey

Lecture notes

  • Tutorial on advanced pattern formation - Amplitude equations and wave fronts,
    Theory of Living Matter group, Cambridge, September 2014 
    Lecture notes (PDF)