| Intracellular calcium release is a prime example for the role of stochastic effects in cellular systems. Recent models consist of deterministic reaction-diffusion equations coupled to stochastic transitions of calcium channels. In this contribution I will first introduce a novel hybrid Gillespie scheme and a finite element code, which are especially tailored to simulate the calcium system. I will then discuss aspects of calcium dynamics from single channel blips to global waves. Random openings of a channel accumulate in bursts of calcium blips that may be central for the understanding of cellular calcium dynamics. For calcium release from a cluster of channels I will discuss in detail the effects of calcium-binding proteins on the dynamics. |
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