| Many neurons exhibit subthreshold membrane-potential resonances, such that the largest voltage responses result from preferred stimulation frequencies. As subthreshold resonances are known to influence the rhythmic activity at the network level, it is vital to understand how they affect spike generation on the single-cell level. Here we analyze the influence of subthreshold resonances on (1) spike-timing reliability and (2) spike patterns. We find that the stimulus frequency resulting in most reliable spike timing correlates with the frequency of subthreshold resonance. Nonlinearities further modify the frequency dependence of spike timing. Furthermore, subthreshold resonance leads to spike clustering, which is explained by a minimal resonate-and-fire type model. |
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