Enzyme-encapsulated quantum dot hydrogels in biosensor development: a multifunctional platform for both bio-catalysis and fluorescent probing

Jipei Yuan

TU Dresden, Physikalische Chemie, Dresden, Germany

Dr. Jipei Yuan, Dr. Nikolai Gaponik and Prof. Dr. Alexander Eychmüller*
Physikalische Chemie, TU Dresden, Bergstrasse 66b, 01062 Dresden, Germany

Quantum dots (QDs) have gained great interest in both fundamental research and in technical applications due to their unique size-dependent physical and optical properties. The assembly of QDs into functional architectures and further applications of these nanomaterials in photovoltaics and in the field of sensing are currently amongst the priorities of QD research [1]. We fabricated enzyme encapsulated mercaptosuccinic acid capped CdTe QDs hydrogels using the sol-gel method, a versatile way in the QD gel formation. The porous three dimensional QD hydrogel turned out to be an adequate encapsulation medium for enzymes and furthermore, the optoelectronic properties of the individual QDs were still retained in the QD hydrogels. The as-prepared enzyme-encapsulated QD hydrogel incorporated both a bio-catalysis unit and the fluorescence signaling unit, and was taken as a multi-functional platform in the development of optical biosensors.

References
[1] I. U. Arachchige, S. L. Brock, Acc. Chem. Res. 2007, 40, 801-809.

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