Assemblies of nanoparticles for remotely controlled molecular trafficking through polymeric and lipid membranes

Andre Skirtach

Max-Planck Instiute of Colloids and Interfaces, Golm, Germany

Ability to control the permeability of polymeric and lipid delivery carriers is one of the most important properties in drug delivery as well as in understanding fundamental properties of membranes. We discuss here molecular trafficking generated through polymeric and lipid membranes by laser nanoparticle interaction. This presentation highlights: assembly of aggregated versus non-aggregated states of nanoparticles on polymeric membranes and assemblies of nanoparticles on lipid membranes. We model temperature distribution on aggregates and stand alone nanoparticles by numerical modelling complemented by an exact analytical solution. Practically, interest to this theme is generated by possibilities of, for example, intracellular and in-vivo release. It also allows to get some insights into molecular trafficking through polymeric and lipid membranes.

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