| The post-translational modification of proteins is a fundamental mechanism in signal transduction, mediating processes in cell differentiation, development and disease. A large number of distinct modifications with a wide range of functions are known (e.g. phosphorylation, methylation, acetylation, glycosylation, ubiquitination, biotinylation, etc.). Histone modifications constitute a complex gene regulatory system, and an extensive body of literature exists especially for lysine methylation. By developing a conceptual and computational framework to integrate various types of data, we aim to identify proteins with novel roles relating to this type of modification. |
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