Alignment of protein-protein interfaces based on the matching of non-covalent interactions

Hongbo Zhu

Technical University Dresden, BIOTEC, Dresden, Germany

We would like to present a method for aligning the vector representations of non-covalent interactions (van der Waals interactions and hydrogen bonds) between different protein-protein interfaces based on their geometry. It assists users in identifying local interface regions with similar patterns of non-covalent interactions, and investigating the molecular basis of interaction mimicry.

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