Catching mass selected peptides and proteins in helium droplets

Gert von Helden

Fritz-Haber-Institut, Molekülphysik, Berlin, Germany

The inside of liquid helium droplets provides an ideal cryo environment for the study of molecules. In most experiments, a beam of helium droplets traverses a gas cell and molecules are picked up by the droplets. A requirement is that the molecule to be investigated has a sufficient vapor pressure. We constructed a setup where the helium droplets do not traverse a gas cell, but an ion trap filled with mass selected ions. This scheme has shown to be very efficient and in first experiments, we succeeded in doping the droplets with species as large as Cytochrome C, a protein containing more than 100 amino acids.

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