Dynamics of Immune Repertoires: Exploration and Translation

International Workshop and Seminar
4 - 29 July 2022

Research on control and decision making in the dynamics of the immune system is evolving at a breathtaking pace. Fast emerging and progressing innovative approaches and technologies, from high throughput to single cell analysis, open new avenues, give new stimuli and create therapeutic possibilities for clinical fields as cancer, autoimmunity and vaccine development. The success of such interventions will heavily benefit from an even deeper knowledge and comprehension of the dynamics and architecture of adaptive immune cells. Key to the adaptive immune system are the responses by T and B cells and their highly diverse receptor repertoires, providing a robust defense against invading pathogens and microorganisms, while maintaining control on autoimmune reactions. Dealing with such large repertoires is the contemporaneous challenge in adaptive immunity research, and present efforts are directed toward characterizing the immune receptor diversity in individual subjects, finding the relationship between the repertoire and immune receptor functionality, as well as to unravel the complex, multiscale dynamics that determine immune response control. In this conference we bring together leading scientists from different disciplines that work on subjects pertaining to control and decision making in the dynamics of immune repertoires, and we will lay a special focus in enhancing cooperations between clinic and basic research institutions. We thereby hope to deeply explore the emerging immune landscape and to bridge some of the gaps between theoretical approaches and clinical research.

• the architecture of immune cell networks
• challenges in computational tools
• determining bridges between repertoire sequences and function
• experimental challenges
• immunopharmacogenomics
• translation to clinics
• bridging innate and adaptive immune system
• molecular recognition by distributed systems